Quick little design (75% of actual size) I put together to a) have a shot at doing a responsive theme concept of this type, and b) see how far I can push some of WP's new built-in customization options without having to resort to my own separate options panel. Should be interesting, and whatever comes out of it will be released for free as both a responsive site template and WordPress theme.
(so here's hoping it doesn't end up sucking ass
Icons: Iconify.it ([link]
Images: Me! (robot = iPad doodle, cthulhu = PS sketch I did years ago under my old dA account)
EDIT: Demo and download the free site template version here: [link]